In Vivo Measurements On Human Lens Using Quasielastic Light Scattering

Peter C. Magnante; Leo T. Chylack; George B. Benedek; Teodosio Libondi

doi:10.1117/12.937336

10 March 1987 In Vivo Measurements On Human Lens Using Quasielastic Light Scattering

Peter C. Magnante, Leo T. Chylack, George B. Benedek, Teodosio Libondi

Proceedings Volume 0712, Lasers in Medicine; (1987) https://doi.org/10.1117/12.937336
Event: Cambridge Symposium-Fiber/LASE '86, 1986, Cambridge, MA, United States

Abstract

Quasi-elastic light scattering is a useful method to determine the size distribution of sub-micron particles in fluids. We have applied this technique to measure in vivo changes in the association of human lens protein constituents that occur with aging and cataractogenesis. The autocorrelation function of the scattered light has been analyzed by a two component exponential where each component is characterized by an intensity and decay rate. Each pair of parameters is associated with one of two major protein compo-nents in the lens. Our results seem to be consistent with the model of progressive aggregation of the lens proteins as detected in vitro by other biochemical methods.

Citation Download Citation

Peter C. Magnante, Leo T. Chylack, George B. Benedek, and Teodosio Libondi "In Vivo Measurements On Human Lens Using Quasielastic Light Scattering", Proc. SPIE 0712, Lasers in Medicine, (10 March 1987); https://doi.org/10.1117/12.937336

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