Optical wire guided lumpectomy: frequency domain measurements

A. L. Dayton; V. T. Keränen; S. A. Prahl

doi:10.1117/12.808242

20 February 2009 Optical wire guided lumpectomy: frequency domain measurements

A. L. Dayton, V. T. Keränen, S. A. Prahl

Proceedings Volume 7173, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications IX; 71730M (2009) https://doi.org/10.1117/12.808242
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

In practice, complete removal of the tumor during a lumpectomy is difficult; the published rates of positive margins range from 10% to 50%. A spherical lumpectomy specimen with tumor directly in the middle may improve the success rate. A light source placed within the tumor may accomplish this goal by creating a sphere surrounding the tumor that can serve as a guide for resection. In an optical phantom and a prophylactic mastectomy specimen, sinusoidally modulated light within the medium was collected by optical fiber(s) at fixed distance(s) from the source and used to measure the optical properties. These optical properties were then used to calculate the distance the light had traveled through the medium. The fiber was coupled to an 830nm diode laser that was modulated at 100, 200 and 300 MHz. A handheld optical probe collected the modulated light and a network analyzer measured the phase lag. This data was used to calculate the distance the light traveled from the emitting fiber tip to the probe. The optical properties were μ_a = 0.004mm^-1 and μ¹_s = 0.38mm^-1 in the phantom. The optical properties for the tissue were μ_a = 0.005mm^-1 and μ¹_s = 0.20mm^-1. The prediction of distance from the source was within 4mm of the actual distance at 30mm in the phantom and within 3mm of the actual distance at 25mm in the tissue. The feasibility of a frequency domain system that makes measurements of local optical properties and then extrapolates those optical properties to make measurements of distance with a separate probe was demonstrated.

Citation Download Citation

A. L. Dayton, V. T. Keränen, and S. A. Prahl "Optical wire guided lumpectomy: frequency domain measurements", Proc. SPIE 7173, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications IX, 71730M (20 February 2009); https://doi.org/10.1117/12.808242

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