Optical mammography: improved sensitivity by combined absorption and fluorescence analysis

Anaïs Leproux; Marjolein van der Voort; Rik Harbers; Wim Verhaegh; Leon Bakker; Tim Nielsen; Bernhard Brendel; Martin van der Mark

doi:10.1117/12.808190

12 February 2009 Optical mammography: improved sensitivity by combined absorption and fluorescence analysis

Anaïs Leproux, Marjolein van der Voort, Rik Harbers, Wim Verhaegh, Leon Bakker, Tim Nielsen, Bernhard Brendel, Martin van der Mark

Author Affiliations +

Proceedings Volume 7174, Optical Tomography and Spectroscopy of Tissue VIII; 71740V (2009) https://doi.org/10.1117/12.808190
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

We present a method to enhance tumor detectability in breasts imaged with our optical fluorescence mammography system. During a measurement, transmission data at 4 wavelengths and fluorescence data for excitation at 1 wavelength are collected after injection of an optical contrast agent. The data are reconstructed into 3D images of the absorption and fluorescence distributions. Combining those images enables the identification of various breast tissue compounds. Here, we investigate the relevance of our method in phantom experiments.

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Anaïs Leproux, Marjolein van der Voort, Rik Harbers, Wim Verhaegh, Leon Bakker, Tim Nielsen, Bernhard Brendel, and Martin van der Mark "Optical mammography: improved sensitivity by combined absorption and fluorescence analysis", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71740V (12 February 2009); https://doi.org/10.1117/12.808190

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