Biophotonics: resonant cavity-based biosensors

Andrea M. Armani

doi:10.1117/12.807329

17 November 2008 Biophotonics: resonant cavity-based biosensors

Andrea M. Armani

Proceedings Volume 7266, Optomechatronic Technologies 2008; 72660F (2008) https://doi.org/10.1117/12.807329
Event: International Symposium on Optomechatronic Technologies, 2008, San Diego, California, United States

Abstract

Optical microcavities have numerous applications, spanning engineering and science disciplines from designing high-performance optical buffers to studying quantum effects. Recently, these devices have begun to probe biological phenomena, behaving as sensitive and specific chemical and biological sensors. The sensitivity is derived from the long photon lifetime inside the cavity, and therefore, devices with higher quality factors (Q) are more sensitive. Specificity is achieved through surface functionalization. Previously, ultra-high-Q (Q>100 million) devices demonstrated label-free, single molecule detection of biologically relevant proteins based on resonant wavelength shift. This work and more recent results using a monoclonal antibody-based surface functionalization will be presented.

Citation Download Citation

Andrea M. Armani "Biophotonics: resonant cavity-based biosensors", Proc. SPIE 7266, Optomechatronic Technologies 2008, 72660F (17 November 2008); https://doi.org/10.1117/12.807329

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