Spectroscopic analysis of pharmaceutical formulations through the use of chemometric tools

N. Ornelas-Soto; O. Barbosa-García; M. Meneses-Nava; G. Ramos-Ortíz; J. Pichardo-Molina; J. L. Maldonado; U. Contreras; L. López-Martínez; P. López-de-Alba; F. López-Barajas

doi:10.1117/12.851128

3 December 2009 Spectroscopic analysis of pharmaceutical formulations through the use of chemometric tools

N. Ornelas-Soto, O. Barbosa-García, M. Meneses-Nava, G. Ramos-Ortíz, J. Pichardo-Molina, J. L. Maldonado, U. Contreras, L. López-Martínez, P. López-de-Alba, F. López-Barajas

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Proceedings Volume 7499, Seventh Symposium Optics in Industry; 74990Z (2009) https://doi.org/10.1117/12.851128
Event: Seventh Symposium on Optics in Industry, 2009, Guadalajara, Jalisco, Mexico

Abstract

In this work, fast and reliable spectroscopic methods in combination with chemometric tools were developed for simultaneous determination of Acetylsalicylic Acid, Acetaminophen and Caffeine in commercial formulations. For the first-order multivariate calibration method (PLS-1), calibration and validation sets were constructed with 23 and 10 samples respectively according to a central composite design. The Micro-Raman, FTIR-HATR and UV absorption spectra in the region of 100-2000 cm^-1, 400-4400 cm^-1 and 200-350 nm, respectively, were recorded. The % REP's (Percentage of relative error of prediction) was less than 18 for all used spectroscopic techniques. Subsequently, commercial pharmaceutical samples were analyzed with percentage of recovery between 90 and 117% for the three compounds.

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N. Ornelas-Soto, O. Barbosa-García, M. Meneses-Nava, G. Ramos-Ortíz, J. Pichardo-Molina, J. L. Maldonado, U. Contreras, L. López-Martínez, P. López-de-Alba, and F. López-Barajas "Spectroscopic analysis of pharmaceutical formulations through the use of chemometric tools", Proc. SPIE 7499, Seventh Symposium Optics in Industry, 74990Z (3 December 2009); https://doi.org/10.1117/12.851128

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