A comparative investigation on linear inversion schemes in fluorescence lifetime tomography

Feng Gao; Meng Jing; Yuting Jiao; Patrick Poulet; Limin Zhang; Huijuan Zhao

doi:10.1117/12.834835

23 February 2010 A comparative investigation on linear inversion schemes in fluorescence lifetime tomography

Feng Gao, Meng Jing, Yuting Jiao, Patrick Poulet, Limin Zhang, Huijuan Zhao

Proceedings Volume 7557, Multimodal Biomedical Imaging V; 75570N (2010) https://doi.org/10.1117/12.834835
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Fluorescence lifetime tomography (FLT) is an emerging imaging modality that seeks for recovering distributions of the fluorescent yield and lifetime inside in vivo tissues. This technique, mainly based on time-domain instrumentation, has found promising applications in small-animal imaging for studying tumor pathology and for drug development. As one of the model-based imaging methods, FLT can be finalized with inverting an underdetermined, ill-posed linear system with regard to both the parameters, for which several methods has been adopted. This paper concisely revises the main facts of three commonly-used linear inversions: algebraic reconstruction technique, truncated singular value decomposition and conjugate gradient descent, and presents a comparative investigation on these methods in terms of the image quality and noise robustness.

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Feng Gao, Meng Jing, Yuting Jiao, Patrick Poulet, Limin Zhang, and Huijuan Zhao "A comparative investigation on linear inversion schemes in fluorescence lifetime tomography", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570N (23 February 2010); https://doi.org/10.1117/12.834835

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KEYWORDS

Reconstruction algorithms

Luminescence

Signal to noise ratio

Tomography

Fluorescence tomography

Picosecond phenomena

Tissues

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