Synthesis and characterization of upconversion emission on lanthanides doped ZrO[sub]2[/sub] nanocrystals coated with SiO[sub]2[/sub] for biological applications

Tzarara López-Luke; Elder De La Rosa; Ana Lilia González-Yebra; Beatriz González-Yebra; Carlos Ángeles-Chávez; David Solís; Pedro Salas; Carlos Saldaña; Octavio Meza

doi:10.1117/12.842993

16 February 2010 Synthesis and characterization of upconversion emission on lanthanides doped ZrO₂ nanocrystals coated with SiO₂ for biological applications

Tzarara López-Luke, Elder De La Rosa, Ana Lilia González-Yebra, Beatriz González-Yebra, Carlos Ángeles-Chávez, David Solís, Pedro Salas, Carlos Saldaña, Octavio Meza

Author Affiliations +

Proceedings Volume 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II; 75760T (2010) https://doi.org/10.1117/12.842993
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Er doped and Yb-Er-Tm codoped ZrO2 nanocrystals of average 80 nm in size were prepared by a sol-gel process with the presence of nonionic (PLURONIC F-127) surfactant, and the up-conversion emission was characterized under IR (980 nm) excitation. The effect of the codoped conditions on the crystalline structure and photoluminescence properties were studied. A strong green emission was produced with 5 mol %, 0.2 mol %, 0.01 mol % of Yb3+-Er3+-Tm3+ codoped ZrO2 respectively. It was prepared Er doped ZrO2 -SiO2 core-shell and SiO2 coated Er doped ZrO2 in 2-propanol and water, respectively. The presence of the silica shell of average of 15 nm in thickness has been confirmed by transmition electron microscopy. Photolumineiscence studies show that the silica shell does not affect the emission when the nanoparticles are excited with 980 nm. The up-converting Yb3+-Er3+-Tm3+ codoped ZrO2 nanocrystal has showed to be a powerful tool to future detection techniques. The viability of the nanoparticles of codoped ZrO2 for biological imaging was confirmed by multiphotonic microscope imaging of cervix tissue with inserted codoped ZrO2 nanoparticles. The cervix tissue has a moderate dysplasia. The nanoparticles were introduced at 80 % of the tissue depth (5 μm) without being functionalized.

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Tzarara López-Luke, Elder De La Rosa, Ana Lilia González-Yebra, Beatriz González-Yebra, Carlos Ángeles-Chávez, David Solís, Pedro Salas, Carlos Saldaña, and Octavio Meza "Synthesis and characterization of upconversion emission on lanthanides doped ZrO₂ nanocrystals coated with SiO₂ for biological applications", Proc. SPIE 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, 75760T (16 February 2010); https://doi.org/10.1117/12.842993

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