On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery

Ahmet Ali Yanik; Min Huang; Alp Artar; Tsung-Yao Chang; Hatice Altug

doi:10.1117/12.860815

10 September 2010 On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery

Ahmet Ali Yanik, Min Huang, Alp Artar, Tsung-Yao Chang, Hatice Altug

Proceedings Volume 7757, Plasmonics: Metallic Nanostructures and Their Optical Properties VIII; 775735 (2010) https://doi.org/10.1117/12.860815
Event: SPIE NanoScience + Engineering, 2010, San Diego, California, United States

Abstract

Performances of surface biosensors are often controlled by the analyte delivery rate to the sensing surface instead of sensors intrinsic detection capabilities. In a microfluidic channel, analyte transports diffusively to the biosensor surface severely limiting its performance. At low concentrations, this limitation, commonly known as mass transport problem, causes impractically long detection times extending from days to months. In this proceeding, we propose and demonstrate a hybrid biosensing platform merging nanoplasmonics and nanofluidics. Unlike conventional approaches where the analytes simply stream pass over the sensing surface, our platform enables targeted delivery of analytes to the sensing surface. Our detection platform is based on extraordinary light transmission effect (EOT) in suspended plasmonic nanohole arrays. The subwavelength size nanoholes here act as nanofluidic channels connecting the microfluidic chambers on both sides of the sensors. In order to materialize our detection platform, we also introduce a novel multilayered micro/nanofluidics scheme allowing three dimensional control of the fluidic flow. Using our platform, we show 14-fold improvement in mass transport rate constant appearing in the exponential term. To fabricate these biosensors, we also introduce a lift-off free plasmonic device fabrication technique based on positive resist electron beam lithography. Simplicity of this fabrication technique allows us to fabricate nanostructures with ease, high yield/reproducibility and minimal surface roughness. As a result, we achieve higher refractive index sensitivities. This fabrication technique can find wide range of applications in nanoplasmonics field by eliminating the need for operationally slow and expensive focused ion beam lithography.

Citation Download Citation

Ahmet Ali Yanik, Min Huang, Alp Artar, Tsung-Yao Chang, and Hatice Altug "On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery", Proc. SPIE 7757, Plasmonics: Metallic Nanostructures and Their Optical Properties VIII, 775735 (10 September 2010); https://doi.org/10.1117/12.860815

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available