Development and validation of a combined photoacoustic micro-ultrasound system for in vivo oxygen saturation estimation

A. Needles; A. Heinmiller; P. Ephrat; D. Bates; C. Bilan-Tracey; C. Theodoropoulos; D. Hirson; F. S. Foster

doi:10.1117/12.875846

18 February 2011 Development and validation of a combined photoacoustic micro-ultrasound system for in vivo oxygen saturation estimation

A. Needles, A. Heinmiller, P. Ephrat, D. Bates, C. Bilan-Tracey, C. Theodoropoulos, D. Hirson, F. S. Foster

Author Affiliations +

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 78992D (2011) https://doi.org/10.1117/12.875846
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Photoacoustic (PA) Imaging can estimate the spatial distribution of oxygen saturation (sO₂) and total hemoglobin concentration (HbT) in blood, and be co-registered with B-Mode ultrasound images of the surrounding anatomy. This study will focus on the development of a PA imaging mode on a commercially available array based micro-ultrasound (μUS) system that is capable of creating such images. The system will then be validated in vivo against a complementary technique for measuring partial pressure of oxygen in blood (pO₂). The pO₂ estimates are converted to sO₂ values based on a standard dissociation curve found in the literature. Finally, the system will be used for assessing oxygenation in a murine model of ischemia, both during injury and recovery.

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A. Needles, A. Heinmiller, P. Ephrat, D. Bates, C. Bilan-Tracey, C. Theodoropoulos, D. Hirson, and F. S. Foster "Development and validation of a combined photoacoustic micro-ultrasound system for in vivo oxygen saturation estimation", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78992D (18 February 2011); https://doi.org/10.1117/12.875846

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