In vivo biodistribution of iron oxide nanoparticles: an overview

Jennifer A. Tate; Alicia A. Petryk; Andrew J. Giustini; P. Jack Hoopes

doi:10.1117/12.876414

23 February 2011 In vivo biodistribution of iron oxide nanoparticles: an overview

Jennifer A. Tate, Alicia A. Petryk, Andrew J. Giustini, P. Jack Hoopes

Proceedings Volume 7901, Energy-based Treatment of Tissue and Assessment VI; 790117 (2011) https://doi.org/10.1117/12.876414
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Iron oxide nanoparticles present a promising alternative to conventional energy deposition-based tissue therapies. The success of such nanoparticles as a therapeutic for diseases like cancer, however, depends heavily on the particles' ability to localize to tumor tissue as well as provide minimal toxicity to surrounding tissues and key organs such as those involved in the reticuloendothelial system (RES). We present here the results of a long term clearance study where mice injected intravenously with 2 mg Fe of 100 nm dextran-coated iron oxide nanoparticles were sacrificed at 14 and 580 days post injection. Histological analysis showed accumulation of the nanoparticles in some RES organs by the 14 day time point and clearance of the nanoparticles by the 580 day time point with no obvious toxicity to organs. An additional study reported herein employs 20 nm and 110 nm starch-coated iron oxide nanoparticles at 80 mg Fe/kg mouse in a size/biodistribution study with endpoints at 4, 24 and 72 hours. Preliminary results show nanoparticle accumulation in the liver and spleen with some elevated iron accumulation in tumoral tissues with differences between the 20 nm and the 110 nm nanoparticle depositions.

Citation Download Citation

Jennifer A. Tate, Alicia A. Petryk, Andrew J. Giustini, and P. Jack Hoopes "In vivo biodistribution of iron oxide nanoparticles: an overview", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 790117 (23 February 2011); https://doi.org/10.1117/12.876414

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