The high-quality spectral fingerprint of glucose captured by Raman spectroscopy in non-invasive glucose measurement

Jeankun Oh; Seongmoon Cho; Hyunho Oh; Yunhee Ku; BongChu Shim; Moosub Kim; Yongju Yang; Dami Kim; Hyejin Eum; David R. Miller

doi:10.1117/12.874314

10 February 2011 The high-quality spectral fingerprint of glucose captured by Raman spectroscopy in non-invasive glucose measurement

Jeankun Oh, Seongmoon Cho, Hyunho Oh, Yunhee Ku, BongChu Shim, Moosub Kim, Yongju Yang, Dami Kim, Hyejin Eum, David R. Miller

Author Affiliations +

Proceedings Volume 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III; 79060G (2011) https://doi.org/10.1117/12.874314
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Optical spectroscopy has the inherent advantage of directly measuring glucose levels by means of the unique nature of a spectral fingerprint for the target analyte, glucose, which is determined in the form of a calibration spectrum (a product of multivariate analysis method). The literature is replete with claims of successful in-vivo glucose measurements in terms of Clark error grid analysis. However, all of them fail to demonstrate an in vivo glucose-specific calibration spectrum. In this study we use Raman spectroscopy to capture a high quality spectral fingerprint of the glucose molecule noninvasively and demonstrate calculated correlation coefficients between a pure glucose spectrum and calibration spectra at over 0.8.

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Jeankun Oh, Seongmoon Cho, Hyunho Oh, Yunhee Ku, BongChu Shim, Moosub Kim, Yongju Yang, Dami Kim, Hyejin Eum, and David R. Miller "The high-quality spectral fingerprint of glucose captured by Raman spectroscopy in non-invasive glucose measurement", Proc. SPIE 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 79060G (10 February 2011); https://doi.org/10.1117/12.874314

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