Protein nanospheres: synergistic nanoplatform-based probes for multimodality imaging

Michael A. McDonald; Paul C. Wang; Eliot L. Siegel

doi:10.1117/12.876081

21 February 2011 Protein nanospheres: synergistic nanoplatform-based probes for multimodality imaging

Michael A. McDonald, Paul C. Wang, Eliot L. Siegel

Proceedings Volume 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III; 79101G (2011) https://doi.org/10.1117/12.876081
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

No single clinical imaging modality has the ability to provide both high resolution and high sensitivity at the anatomical, functional and molecular level. Synergistically integrated detection techniques overcome these barriers by combining the advantages of different imaging modalities while reducing their disadvantages. We report the development of protein nanospheres optimized for enhancing MRI, CT and US contrast while also providing high sensitivity optical detection. Transferrin protein nanospheres (TfpNS), silicon coated, doped rare earth oxide and rhodamine B isothiocyanate nanoparticles, Si⊂Gd₂O₃:Eu,RBITC, (NP) and transferrin protein nanospheres encapsulating Si⊂Gd₂O₃:Eu,RBITC nanoparticles (TfpNS-NP) were prepared in tissue-mimicking phantoms and imaged utilizing multiple cross-sectional imaging modalities. Preliminary results indicate a 1:1 NP to TfpNS ratio in TfpNS-NP and improved sensitivity of detection for MRI, CT, US and fluorescence imaging relative to its component parts and/or many commercially available contrast agents.

Citation Download Citation

Michael A. McDonald, Paul C. Wang, and Eliot L. Siegel "Protein nanospheres: synergistic nanoplatform-based probes for multimodality imaging", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101G (21 February 2011); https://doi.org/10.1117/12.876081

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