Chemical binding affinity estimation using MSB

John B. Weaver; Adam M. Rauwerdink

doi:10.1117/12.878788

15 March 2011 Chemical binding affinity estimation using MSB

John B. Weaver, Adam M. Rauwerdink

Proceedings Volume 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging; 79650Y (2011) https://doi.org/10.1117/12.878788
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

Binding affinity can be estimated in several ways in the laboratory but there is no viable way to estimate binding affinity in vivo without assumptions on the number of binding sites. Magnetic spectroscopy of nanoparticle Brownian motion, MSB, measures the rotational Brownian motion. The MSB signal is affected by nanoparticle binding affinity so it provides a mechanism to measure the chemical binding affinity. We present a possible mechanism to quantify the binding affinity and test that mechanism using viscous solutions.

Citation Download Citation

John B. Weaver and Adam M. Rauwerdink "Chemical binding affinity estimation using MSB", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650Y (15 March 2011); https://doi.org/10.1117/12.878788

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