Human pulmonary acinar airspace segmentation from three-dimensional synchrotron radiation micro CT images of secondary pulmonary lobule

Y. Kawata; T. Hosokawa; N. Niki; K. Umetani; Y. Nakano; H. Ohmatsu; N. Moriyama; H. Itoh

doi:10.1117/12.877938

9 March 2011 Human pulmonary acinar airspace segmentation from three-dimensional synchrotron radiation micro CT images of secondary pulmonary lobule

Y. Kawata, T. Hosokawa, N. Niki, K. Umetani, Y. Nakano, H. Ohmatsu, N. Moriyama, H. Itoh

Author Affiliations +

Proceedings Volume 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging; 79651P (2011) https://doi.org/10.1117/12.877938
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

The recognition of abnormalities relative to the lobular anatomy has become increasingly important in the diagnosis and differential diagnosis of lung abnormalities at clinical routines of CT examinations. This paper aims for a 3-D microstructural analysis of the pulmonary acinus with isotropic spatial resolution in the range of several micrometers by using micro CT. Previously, we demonstrated the ability of synchrotron radiation micro CT (SRμCT) using offset scan mode in microstructural analysis of the whole part of the secondary pulmonary lobule. In this paper, we present a semi-automatic method to segment the acinar and subacinar airspaces from the secondary pulmonary lobule imaged by the SRμCT. The method began with a segmentation of the tissues such as pleural surface, interlobular septa, alveola wall, or vessel using threshold technique and 3-D connected component analysis. Follow-on stages then constructed 3-D air space separated by tissues and represented branching patterns of airways and airspaces distal to the terminal bronchiole. Finally, a graph-partitioning approach isolated acini whose stems were interactively defined as the terminal bronchiole in the secondary pulmonary lobule. Additionally, the isolated acinar airspace was segmented into subacini in which the airway was considered as the stem using the graph-partitioning approach. Results demonstrate that the proposed method can extract several acinar airspaces from the 3-D SRμCT image of secondary pulmonary lobule and that the extracted acinar airspace enable an accurate quantitative description of the anatomy of the human acinus for interpretation of the basic unit of pulmonary structure and function.

Citation Download Citation

Y. Kawata, T. Hosokawa, N. Niki, K. Umetani, Y. Nakano, H. Ohmatsu, N. Moriyama, and H. Itoh "Human pulmonary acinar airspace segmentation from three-dimensional synchrotron radiation micro CT images of secondary pulmonary lobule", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79651P (9 March 2011); https://doi.org/10.1117/12.877938

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Image segmentation

Lung

3D image processing

Synchrotron radiation

Tissues

Computed tomography

X-ray computed tomography

Show All Keywords

Keywords/Phrases

Search In:

Publication Years