Numerical modeling of light propagation in biological tissues: time-resolved 3D simulations based on light diffusion model and FDTD solution of Maxwell's equations

N. Ortega-Quijano; O. G. Romanov; F. Fanjul-Vélez; I. Salas-García; A. L. Tolstik; J. L. Arce-Diego

doi:10.1117/12.889826

14 June 2011 Numerical modeling of light propagation in biological tissues: time-resolved 3D simulations based on light diffusion model and FDTD solution of Maxwell's equations

N. Ortega-Quijano, O. G. Romanov, F. Fanjul-Vélez, I. Salas-García, A. L. Tolstik, J. L. Arce-Diego

Author Affiliations +

Proceedings Volume 8088, Diffuse Optical Imaging III; 80881R (2011) https://doi.org/10.1117/12.889826
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

In this work, optical propagation through turbid media is analyzed by FDTD simulation. In particular, the method is applied to biological tissues. Continuous light propagation in turbid media has been widely studied, but pulsed light propagation has received less interest due to its complexity. Therefore, in this work we focus on pulsed light. FDTD method is applied to several media with optical parameters in the typical range of those observed in biological tissues. We perform an analysis of the variations of pulsed light propagation as a function of the scatterers characteristics (namely size, concentration, and optical contrast). The results are compared with those obtained by the use of the diffusion approximation. The potential of the FDTD method over the diffusion model is given by its high accuracy, its capacity to perform time-resolved simulations, and the fact that it carries all the information about the phase and coherence of the wavefront. The results of this work can be applied to a wide range of areas of interest like the time-resolved study of ultrashort light pulses propagation, the optimization of optical penetration depth, the coherence properties of pulsed light, and the effect of modified wavefronts in light propagation.

Citation Download Citation

N. Ortega-Quijano, O. G. Romanov, F. Fanjul-Vélez, I. Salas-García, A. L. Tolstik, and J. L. Arce-Diego "Numerical modeling of light propagation in biological tissues: time-resolved 3D simulations based on light diffusion model and FDTD solution of Maxwell's equations", Proc. SPIE 8088, Diffuse Optical Imaging III, 80881R (14 June 2011); https://doi.org/10.1117/12.889826

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Finite-difference time-domain method

Tissues

Diffusion

Geometrical optics

Scattering

Light wave propagation

Tissue optics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years