Bimetallic chips for SMX sensing in a surface plasmon resonance instrument

Yong Chen; Yonghua Lu; Douguo Zhang; Pei Wang; Hai Ming

doi:10.1117/12.904715

5 December 2011 Bimetallic chips for SMX sensing in a surface plasmon resonance instrument

Yong Chen, Yonghua Lu, Douguo Zhang, Pei Wang, Hai Ming

Proceedings Volume 8198, 2011 International Conference on Optical Instruments and Technology: Optoelectronic Devices and Integration; 81980J (2011) https://doi.org/10.1117/12.904715
Event: International Conference on Optical Instruments and Technology (OIT2011), 2011, Beijing, Beijing, China

Abstract

We replace a commonly used Au film with an Au/Ag bimetallic film working as the sensing chip in the commercial surface plasmon resonance (SPR) instrument, Biacore 3000. The bimetallic chip gives out sharper SPR dip than that by the chip made of an Au film which can improve the sensitivity and accuracy. The applicability and stability of the bimetallic chip on the Biacore 3000 are tested by real-time monitoring of biological coupling processes between Sulfamethoxazole (SMX) and anti-SMX. The limit of detection of SMX is 1.8ng/ml.

Citation Download Citation

Yong Chen, Yonghua Lu, Douguo Zhang, Pei Wang, and Hai Ming "Bimetallic chips for SMX sensing in a surface plasmon resonance instrument", Proc. SPIE 8198, 2011 International Conference on Optical Instruments and Technology: Optoelectronic Devices and Integration, 81980J (5 December 2011); https://doi.org/10.1117/12.904715

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available