Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin

Jiwei Huang; Jeff S. Xu; Carl Schmidt; Ronald X. Xu

doi:10.1117/12.907110

14 February 2012 Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin

Jiwei Huang, Jeff S. Xu, Carl Schmidt, Ronald X. Xu

Proceedings Volume 8216, Multimodal Biomedical Imaging VII; 821604 (2012) https://doi.org/10.1117/12.907110
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We developed a heat-sensitive microbubble (HSM) agent for intraoperative assessment of thermal ablation margins in cancer ablation therapies. The HSM agent, comprising a core of liquid perfluorocarbon (PFC) compound and a shell of biodegradable poly lactic-coglycolic acid (PLGA), was fabricated using an emulsion evaporation method. In our previous study, significant increase of ultrasound contrast was observed after heat activation of HSMs. In this study, intraoperative ultrasonic assessment of thermal ablation margins by HSMs was demonstrated in vivo in a pig model. HSMs were delivered to the pig liver by portal vein injection. Liver ablation was done using a RF ablation probe. Intraoperative ultrasound imaging with HSMs clearly delineated the ablation margin. Fluorescence images of liver tissue samples confirmed the existence and activation of HSMs. This result demonstrated that the HSM agent can be potentially utilized as a multimodal contrast agent for intraoperative ultrasonic and fluorescence assessment of thermal ablation margins in cancer ablation therapies.

Citation Download Citation

Jiwei Huang, Jeff S. Xu, Carl Schmidt, and Ronald X. Xu "Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin", Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 821604 (14 February 2012); https://doi.org/10.1117/12.907110

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KEYWORDS

Liver

Luminescence

Tissues

Cancer

Tissue optics

Photography

Rhodamine B

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