In vivo imaging with GRIN-lens optical resolution photoacoustic micro-endoscopy

Parsin Hajireza; Wei Shi; Alexander Forbrich; Peng Shao; Roger J. Zemp

doi:10.1117/12.909058

23 February 2012 In vivo imaging with GRIN-lens optical resolution photoacoustic micro-endoscopy

Parsin Hajireza, Wei Shi, Alexander Forbrich, Peng Shao, Roger J. Zemp

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 82230I (2012) https://doi.org/10.1117/12.909058
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

In this paper we introduce a novel optical resolution photoacoustic micro-endoscopy system using GRIN-lens focusing. This real-time imaging system takes advantage of an image guide fiber consisting of 100,000 individual single-mode fibers in a 1.4-mm-diameter bundle, and a 532-nm fiber laser with repetition-rates as high as 600 kHz. Fast scanning mirrors were used to scan the entire image guide fiber allowing for the maximum field-of-view. The ability of the proposed system is demonstrated using both phantom and in vivo studies. The system offers <7 μm lateral spatial resolution and several volumetric/C-scans per second frame-rate. The proposed setup can be inserted into the body due to the flexible nature of the image guide and micron-scale footprint of the apparatus.

Citation Download Citation

Parsin Hajireza, Wei Shi, Alexander Forbrich, Peng Shao, and Roger J. Zemp "In vivo imaging with GRIN-lens optical resolution photoacoustic micro-endoscopy", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230I (23 February 2012); https://doi.org/10.1117/12.909058

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