Novel MRI methodology to detect human whole-brain connectivity changes after ingestion of fructose or glucose

Sinchai Tsao; Bryce Wilkins; Kathleen A. Page; Manbir Singh

doi:10.1117/12.906456

12 April 2012 Novel MRI methodology to detect human whole-brain connectivity changes after ingestion of fructose or glucose

Sinchai Tsao, Bryce Wilkins, Kathleen A. Page, Manbir Singh

Author Affiliations +

Proceedings Volume 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging; 831703 (2012) https://doi.org/10.1117/12.906456
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

A novel MRI protocol has been developed to investigate the differential effects of glucose or fructose consumption on whole-brain functional brain connectivity. A previous study has reported a decrease in the fMRI blood oxygen level dependent (BOLD) signal of the hypothalamus following glucose ingestion, but due to technical limitations, was restricted to a single slice covering the hypothalamus, and thus unable to detect whole-brain connectivity. In another previous study, a protocol was devised to acquire whole-brain fMRI data following food intake, but only after restricting image acquisition to an MR sampling or repetition time (TR) of 20s, making the protocol unsuitable to detect functional connectivity above 0.025Hz. We have successfully implemented a continuous 36-min, 40 contiguous slices, whole-brain BOLD acquisition protocol on a 3T scanner with TR=4.5s to ensure detection of up to 0.1Hz frequencies for whole-brain functional connectivity analysis. Human data were acquired first with ingestion of water only, followed by a glucose or fructose drink within the scanner, without interrupting the scanning. Whole-brain connectivity was analyzed using standard correlation methodology in the 0.01-0.1 Hz range. The correlation coefficient differences between fructose and glucose ingestion among targeted regions were converted to t-scores using the water-only correlation coefficients as a null condition. Results show a dramatic increase in the hypothalamic connectivity to the hippocampus, amygdala, insula, caudate and the nucleus accumben for fructose over glucose. As these regions are known to be key components of the feeding and reward brain circuits, these results suggest a preference for fructose ingestion.

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Sinchai Tsao, Bryce Wilkins, Kathleen A. Page, and Manbir Singh "Novel MRI methodology to detect human whole-brain connectivity changes after ingestion of fructose or glucose", Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 831703 (12 April 2012); https://doi.org/10.1117/12.906456

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KEYWORDS

Glucose

Functional magnetic resonance imaging

Brain

Head

Magnetic resonance imaging

Data acquisition

Scanners

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