Sensitivity enhancement and detection-limit improvement in whispering-gallery-mode-based biosensing

Bei-Bei Li; Xu Yi; Qiu-Shu Chen; Yong-Chun Liu; Yun-Feng Xiao

doi:10.1117/12.918401

19 May 2012 Sensitivity enhancement and detection-limit improvement in whispering-gallery-mode-based biosensing

Bei-Bei Li, Xu Yi, Qiu-Shu Chen, Yong-Chun Liu, Yun-Feng Xiao

Proceedings Volume 8376, Photonic Microdevices/Microstructures for Sensing IV; 837607 (2012) https://doi.org/10.1117/12.918401
Event: SPIE Defense, Security, and Sensing, 2012, Baltimore, Maryland, United States

Abstract

In whispering-gallery-mode (WGM) microresonator based optical biosensors, the mode shift or splitting induced by biomolecules are typically regarded as the sensing signals. Here we propose several schemes to improve the performance of WGM based biosensing. In the mode shift sensing scheme, we propose to use a novel exterior plasmonic WGM supported by a metal-coated toroidal microresonator, and the detection sensitivity reaches 500 nm/RIU (refraction index unit). In the mode splitting scheme, we study and discuss how to extend the detection range, which is of importance in detecting small-sized biomolecules. Finally, the single nanoparticle detection is realized experimentally by using mode splitting sensing scheme in the aqueous environment.

Citation Download Citation

Bei-Bei Li, Xu Yi, Qiu-Shu Chen, Yong-Chun Liu, and Yun-Feng Xiao "Sensitivity enhancement and detection-limit improvement in whispering-gallery-mode-based biosensing", Proc. SPIE 8376, Photonic Microdevices/Microstructures for Sensing IV, 837607 (19 May 2012); https://doi.org/10.1117/12.918401

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