Time of correlation of low-frequency fluctuations in the regional laser Doppler flow signal from human skin

M. S. Folgosi-Correa; G. E. C. Nogueira

doi:10.1117/12.921288

8 May 2012 Time of correlation of low-frequency fluctuations in the regional laser Doppler flow signal from human skin

M. S. Folgosi-Correa, G. E. C. Nogueira

Proceedings Volume 8427, Biophotonics: Photonic Solutions for Better Health Care III; 84272D (2012) https://doi.org/10.1117/12.921288
Event: SPIE Photonics Europe, 2012, Brussels, Belgium

Abstract

The laser Doppler flowmetry allows the non-invasive assessment of the skin perfusion in real-time, being an attractive technique to study the human microcirculation in clinical settings. Low-frequency oscillations in the laser Doppler blood flow signal from the skin have been related to the endothelial, endothelial-metabolic, neurogenic and myogenic mechanisms of microvascular flow control, in the range 0.005-0.0095 Hz, 0.0095-0.021 Hz, 0.021-0.052 Hz and 0.052- 0.145 Hz respectively. The mean Amplitude (A) of the periodic fluctuations in the laser Doppler blood flow signal, in each frequency range, derived from the respective wavelet-transformed coefficients, has been used to assess the function and dysfunctions of each mechanism of flow control. Known sources of flow signal variances include spatial and temporal variability, diminishing the discriminatory capability of the technique. Here a new time domain method of analysis is proposed, based on the Time of Correlation (TC) of flow fluctuations between two adjacent sites. Registers of blood flow from two adjacent regions, for skin temperature at 32 ⁰C (basal) and thermally stimulated (42 ⁰C) of volar forearms from 20 healthy volunteers were collected and analyzed. The results obtained revealed high time of correlation between two adjacent regions when thermally stimulated, for signals in the endothelial, endothelial-metabolic, neurogenic and myogenic frequency ranges. Experimental data also indicate lower variability for TC when compared to A, when thermally stimulated, suggesting a new promising parameter for assessment of the microvascular flow control.

Citation Download Citation

M. S. Folgosi-Correa and G. E. C. Nogueira "Time of correlation of low-frequency fluctuations in the regional laser Doppler flow signal from human skin", Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 84272D (8 May 2012); https://doi.org/10.1117/12.921288

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KEYWORDS

Doppler effect

Skin

Electronic filtering

Blood circulation

Filtering (signal processing)

Optical filters

Signal processing

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