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24 October 2012 Advanced biohybrid materials based on nanoclays for biomedical applications
Eduardo Ruiz-Hitzky, Margarita Darder, Bernd Wicklein, Francisco M. Fernandes, Fidel A. Castro-Smirnov, M. Angeles Martín del Burgo, Gustavo del Real, Pilar Aranda
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Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 85480D (2012) https://doi.org/10.1117/12.999995
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of
Abstract
Bio-nanohybrids prepared by assembling natural polymers (polysaccharides, proteins, nucleic acids, etc) to nanosized silicates (nanoclays) and related solids (layered double hydroxides, LDHs) give rise to the so-called bionanocomposites constituting a group of biomaterials with potential applications in medicine. In this way, biopolymers, including chitosan, pectin, alginate, xanthan gum, ι-carrageenan, gelatin, zein, and DNA, as well as phospholipids such as phosphatidylcholine, have been incorporated in layered host matrices by means of ion-exchange mechanisms producing intercalation composites. Also bio-nanohybrids have been prepared by the assembly of diverse bio-polymers with sepiolite, a natural microfibrous magnesium silicate, in this case through interactions affecting the external surface of this silicate. The properties and applications of these resulting biomaterials as active phases of ion-sensors and biosensors, for potential uses as scaffolds for tissue engineering, drug delivery, and gene transfection systems, are introduced and discussed in this work. It is also considered the use of synthetic bionanocomposites as new substrates to immobilize microorganisms, as for instance to bind Influenza virus particles, allowing their application as effective low-cost vaccine adjuvants and carriers.
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Eduardo Ruiz-Hitzky, Margarita Darder, Bernd Wicklein, Francisco M. Fernandes, Fidel A. Castro-Smirnov, M. Angeles Martín del Burgo, Gustavo del Real, and Pilar Aranda "Advanced biohybrid materials based on nanoclays for biomedical applications", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85480D (24 October 2012); https://doi.org/10.1117/12.999995
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KEYWORDS
Silicates
Biopolymers
Minerals
Polymers
Biomedical optics
Particles
Biomimetics
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