Magnetic resonance imaging using chemical exchange saturation transfer

Jaeseok Park

doi:10.1117/12.1000016

24 October 2012 Magnetic resonance imaging using chemical exchange saturation transfer

Jaeseok Park

Author Affiliations +

Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 854846 (2012) https://doi.org/10.1117/12.1000016
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of

Abstract

Magnetic resonance imaging (MRI) has been widely used as a valuable diagnostic imaging modality that exploits water content and water relaxation properties to provide both structural and functional information with high resolution. Chemical exchange saturation transfer (CEST) in MRI has been recently introduced as a new mechanism of image contrast, wherein exchangeable protons from mobile proteins and peptides are indirectly detected through saturation transfer and are not observable using conventional MRI. It has been demonstrated that CEST MRI can detect important tissue metabolites and byproducts such as glucose, glycogen, and lactate. Additionally, CEST MRI is sensitive to pH or temperature and can calibrate microenvironment dependent on pH or temperature. In this work, we provide an overview on recent trends in CEST MRI, introducing general principles of CEST mechanism, quantitative description of proton transfer process between water pool and exchangeable solute pool in the presence or absence of conventional magnetization transfer effect, and its applications

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Jaeseok Park "Magnetic resonance imaging using chemical exchange saturation transfer", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 854846 (24 October 2012); https://doi.org/10.1117/12.1000016

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KEYWORDS

Magnetic resonance imaging

Water

Calibration

Proteins

Data acquisition

Diagnostics

Glucose

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