Measurement of in vivo basal-turn vibrations of the organ of Corti
using phase-sensitive Fourier domain optical coherence tomography

Sripriya Ramamoorthy; Yuan Zhang; Tracy Petrie; Fangyi Chen; Hrebesh Molly Subhash; Niloy Choudhury; Ruikang Wang; Steven L. Jacques; Alfred L. Nuttall

doi:10.1117/12.2009260

8 March 2013 Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography

Sripriya Ramamoorthy, Yuan Zhang, Tracy Petrie, Fangyi Chen, Hrebesh Molly Subhash, Niloy Choudhury, Ruikang Wang, Steven L. Jacques, Alfred L. Nuttall

Author Affiliations +

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 85651V (2013) https://doi.org/10.1117/12.2009260
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

A major reason we can perceive faint sounds and communicate in noisy environments is that the outer hair cells of the organ of Corti enhance the sound-evoked motions inside the cochlea. To understand how the organ of Corti works, we have built and tested the phase-sensitive Fourier domain optical coherence tomography (PSFDOCT) system. This system has key advantages over our previous time domain OCT system [1]. The PSFDOCT system has better signal to noise and simultaneously acquires vibration data from all points along the optical-axis [2]. Feasibility of this system to measure in vitro cochlear vibrations in the apex was demonstrated earlier [3]. In this study, we measure the in vivo vibrations of the organ of Corti via round window in live anaesthetized guinea pigs using PSFDOCT. This region of the guinea pig cochlea responds to very high frequencies (10 - 40 kHz). The current vibration noise floor for native organ of Corti tissue is 0.03 nm in this frequency range. Sound-induced vibrations of the stapes, which delivers input to the cochlea, are also measured. The measured vibrations of the organ of Corti demonstrate non-linear compression and active amplification characteristic of sensitive mammalian cochlea.

Citation Download Citation

Sripriya Ramamoorthy, Yuan Zhang, Tracy Petrie, Fangyi Chen, Hrebesh Molly Subhash, Niloy Choudhury, Ruikang Wang, Steven L. Jacques, and Alfred L. Nuttall "Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85651V (8 March 2013); https://doi.org/10.1117/12.2009260

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