An ultrasound-guided fluorescence tomography system: design and  specification

Alisha V. D'Souza; Brendan P. Flynn; Stephen C. Kanick; Sason Torosean; Scott C. Davis; Edward V. Maytin; Tayyaba Hasan; Brian W. Pogue

doi:10.1117/12.2007504

13 March 2013 An ultrasound-guided fluorescence tomography system: design and specification

Alisha V. D'Souza, Brendan P. Flynn, Stephen C. Kanick, Sason Torosean, Scott C. Davis, Edward V. Maytin, Tayyaba Hasan, Brian W. Pogue

Author Affiliations +

Proceedings Volume 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII; 85681A (2013) https://doi.org/10.1117/12.2007504
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

An ultrasound-guided fluorescence molecular tomography system is under development for in vivo quantification of Protoporphyrin IX (PpIX) during Aminolevulinic Acid - Photodynamic Therapy (ALA-PDT) of Basal Cell Carcinoma. The system is designed to combine fiber-based spectral sampling of PPIX fluorescence emission with co-registered ultrasound images to quantify local fluorophore concentration. A single white light source is used to provide an estimate of the bulk optical properties of tissue. Optical data is obtained by sequential illumination of a 633nm laser source at 4 linear locations with parallel detection at 5 locations interspersed between the sources. Tissue regions from segmented ultrasound images, optical boundary data, white light-informed optical properties and diffusion theory are used to estimate the fluorophore concentration in these regions. Our system and methods allow interrogation of both superficial and deep tissue locations up to PpIX concentrations of 0.025ug/ml.

Citation Download Citation

Alisha V. D'Souza, Brendan P. Flynn, Stephen C. Kanick, Sason Torosean, Scott C. Davis, Edward V. Maytin, Tayyaba Hasan, and Brian W. Pogue "An ultrasound-guided fluorescence tomography system: design and specification", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85681A (13 March 2013); https://doi.org/10.1117/12.2007504

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Luminescence

Tissue optics

Ultrasonography

Image segmentation

Optical filters

Data acquisition

Fluorescence tomography

Show All Keywords

Keywords/Phrases

Search In:

Publication Years