Optical characterization of two-layered tissue-like phantoms using multi-distance, frequency domain near-infrared spectroscopy

Bertan Hallacoglu; Angelo Sassaroli; Sergio Fantini

doi:10.1117/12.2002453

25 March 2013 Optical characterization of two-layered tissue-like phantoms using multi-distance, frequency domain near-infrared spectroscopy

Bertan Hallacoglu, Angelo Sassaroli, Sergio Fantini

Author Affiliations +

Proceedings Volume 8578, Optical Tomography and Spectroscopy of Tissue X; 85780B (2013) https://doi.org/10.1117/12.2002453
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We present a near-infrared spectroscopy (NIRS) approach for the optical characterization of two-layered tissuemimicking phantoms. For the data acquisition, we employed a multi-distance frequency-domain system. For the data analysis, we implemented an inversion routine based on a two-layered solution of the frequency-domain diffusion equation as the forward model. Measured quantities were the absorption and reduced scattering coefficients of the first layer (μ_a1, μ’_s1) and the second layer (μ_a2, μ’_s2), and the thickness of the first layer (L). We report measurements on three two-layered liquid phantoms featuring absorption coefficients in the range 0.009-0.017 mm^-1, reduced scattering coefficients in the range 0.69-0.92 mm^-1, and first layer thickness in the range 8-15 mm. Our method yielded measured values of the optical coefficients and first layer thickness (μ_a1, μ’_s1, μ_a2, μ’_s2, and L) that are within 10% of the true values (optical properties measured in the infinite geometry; and the true first layer thickness). These are promising results toward exploring the potential of this two-layered medium approach in the human head, where the two layers would represent extracerebral and cerebral tissue, respectively.

Citation Download Citation

Bertan Hallacoglu, Angelo Sassaroli, and Sergio Fantini "Optical characterization of two-layered tissue-like phantoms using multi-distance, frequency domain near-infrared spectroscopy", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780B (25 March 2013); https://doi.org/10.1117/12.2002453

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Tissue optics

Optical testing

Near infrared spectroscopy

Optical properties

Absorption

Data modeling

Diffusion

Show All Keywords

Keywords/Phrases

Search In:

Publication Years