Glucose measurement by surface plasmon resonance with borate polymer binding

Dachao Li; Jia Yang; Peng Wu; Di Yang; Bo Wang; Yuan Lin; Kexin Xu

doi:10.1117/12.2003468

25 February 2013 Glucose measurement by surface plasmon resonance with borate polymer binding

Dachao Li, Jia Yang, Peng Wu, Di Yang, Bo Wang, Yuan Lin, Kexin Xu

Proceedings Volume 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics; 85910P (2013) https://doi.org/10.1117/12.2003468
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Minimally-invasive human blood glucose detection can be realized by measuring the glucose concentration of interstitial fluid to predict the blood glucose level. As the amount of transdermally extracted interstitial fluid was minimal and its composition was complex, a glucose measurement method by surface plasmon resonance (SPR) based on PAA-ran-PAAPBA polymer binding was proposed. The polymer was immobilized on the gold film of SPR sensor using layer-by-layer self-assembly technique to capture the glucose molecules in interstitial fluid to realize the detection of glucose concentration with high precision. 2~1000mg/dL glucose solutions were measured utilizing the SPR sensor by polymer binding. The fitting degrees were 0.90177 and 0.99509 in the range of 2~10mg/dL and 25~1000mg/dL respectively. The dynamic dissociation process of glucose molecules from PAA-ran-PAAPBA was verified to be able to satisfy the requirements of the human blood glucose continuous monitoring in clinics.

Citation Download Citation

Dachao Li, Jia Yang, Peng Wu, Di Yang, Bo Wang, Yuan Lin, and Kexin Xu "Glucose measurement by surface plasmon resonance with borate polymer binding", Proc. SPIE 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics, 85910P (25 February 2013); https://doi.org/10.1117/12.2003468

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available