Pulmonary ultrasound elastography: a feasibility study with phantoms and ex-vivo tissue

Man Minh Nguyen; Hua Xie; Kamila Paluch; Douglas Stanton; Bharat Ramachandran

doi:10.1117/12.2007354

29 March 2013 Pulmonary ultrasound elastography: a feasibility study with phantoms and ex-vivo tissue

Man Minh Nguyen, Hua Xie, Kamila Paluch, Douglas Stanton, Bharat Ramachandran

Proceedings Volume 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy; 867503 (2013) https://doi.org/10.1117/12.2007354
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Elastography has become widely used for minimally invasive diagnosis in many tumors as seen with breast, liver and prostate. Among different modalities, ultrasound-based elastography stands out due to its advantages including being safe, real-time, and relatively low-cost. While lung cancer is the leading cause of cancer mortality among both men and women, the use of ultrasound elastography for lung cancer diagnosis has hardly been investigated due to the limitations of ultrasound in air. In this work, we investigate the use of static-compression based endobronchial ultrasound elastography by a 3D trans-oesophageal echocardiography (TEE) transducer for lung cancer diagnosis. A water-filled balloon was designed to 1) improve the visualization of endobronchial ultrasound and 2) to induce compression via pumping motion inside the trachea and bronchiole. In a phantom study, we have successfully generated strain images indicating the stiffness difference between the gelatin background and agar inclusion. A similar strain ratio was confirmed with Philips ultrasound strain-based elastography product. For ex-vivo porcine lung study, different tissue ablation methods including chemical injection, Radio Frequency (RF) ablation, and direct heating were implemented to achieve tumor-mimicking tissue. Stiff ablated lung tissues were obtained and detected with our proposed method. These results suggest the feasibility of pulmonary elastography to differentiate stiff tumor tissue from normal tissue.

Citation Download Citation

Man Minh Nguyen, Hua Xie, Kamila Paluch, Douglas Stanton, and Bharat Ramachandran "Pulmonary ultrasound elastography: a feasibility study with phantoms and ex-vivo tissue", Proc. SPIE 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, 867503 (29 March 2013); https://doi.org/10.1117/12.2007354

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