Photoacoustic tomography assessment of vascular targeted therapy to determine vessel regrowth following treatment

S. P. Johnson; O. Ogunlade; E. Zhang; J. Laufer; V. Rajkumar; S. Walker-Samuel; M. F. Lythgoe; R. B. Pedley; P. Beard P.

doi:10.1117/12.2033417

14 June 2013 Photoacoustic tomography assessment of vascular targeted therapy to determine vessel regrowth following treatment

S. P. Johnson, O. Ogunlade, E. Zhang, J. Laufer, V. Rajkumar, S. Walker-Samuel, M. F. Lythgoe, R. B. Pedley, P. Beard P.

Author Affiliations +

Proceedings Volume 8800, Opto-Acoustic Methods and Applications; 880008 (2013) https://doi.org/10.1117/12.2033417
Event: European Conferences on Biomedical Optics, 2013, Munich, Germany

Abstract

Photoacoustic tomography (PAT) is ideally suited to image tissue vasculature and is therefore able to provide functional response data for the pharmacodynamic time course of vascular targeted therapies. We show in a preclinical model of colorectal carcinoma that 40mg/kg of the vascular disrupting agent OXi4503 causes central tumour blood vessel destruction that can be assessed by PAT at 48 hours. This is confirmed with histological haematoxylin and eosin staining. Outward growth of solid tumours is then static until 16 days post-dose whilst vessel regrowth occurs inwardly to repopulate the necrotic core.

Citation Download Citation

S. P. Johnson, O. Ogunlade, E. Zhang, J. Laufer, V. Rajkumar, S. Walker-Samuel, M. F. Lythgoe, R. B. Pedley, and P. Beard P. "Photoacoustic tomography assessment of vascular targeted therapy to determine vessel regrowth following treatment", Proc. SPIE 8800, Opto-Acoustic Methods and Applications, 880008 (14 June 2013); https://doi.org/10.1117/12.2033417

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KEYWORDS

Acquisition tracking and pointing

Photoacoustic tomography

Photoacoustic spectroscopy

Blood vessels

Skin

Tissue optics

Solids

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