Generation and biological evaluation of the products formed from the exposure of Phenothiazine to a 266nm laser beam

T. Alexandru; M. L. Pascu; B. Danko; V. Nastasa; M. Boni; A. Militaru; I. R. Andrei; A. Staicu; A. Hunyadi; A. Armada; M. Viveiros; L. Amaral

doi:10.1117/12.2032666

10 June 2013 Generation and biological evaluation of the products formed from the exposure of Phenothiazine to a 266nm laser beam

T. Alexandru, M. L. Pascu, B. Danko, V. Nastasa, M. Boni, A. Militaru, I. R. Andrei, A. Staicu, A. Hunyadi, A. Armada, M. Viveiros, L. Amaral

Author Affiliations +

Proceedings Volume 8882, ROMOPTO 2012: Tenth Conference on Optics: Micro- to Nanophotonics III; 88820T (2013) https://doi.org/10.1117/12.2032666
Event: ROMOPTO International Conference on Micro- to Nano-Photonics III, 2012, Bucharest, Romania

Abstract

Phenothiazine exposed to white light or UV radiation undergoes a variety of reactions that result in the degradation of the parental compound and the formation of new species. Chlorpromazine exposed to the 266 nm laser beam of given energy levels yielded species derived from it, whose number increased with the exposure duration. At distinct time intervals the irradiation products were evaluated by spectrophotometry between 200-1500 nm, Thin Layer Chromatography, and for antimicrobial activity of Chlorpromazine against different test organisms such as Staphylococcus aureus.

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T. Alexandru, M. L. Pascu, B. Danko, V. Nastasa, M. Boni, A. Militaru, I. R. Andrei, A. Staicu, A. Hunyadi, A. Armada, M. Viveiros, and L. Amaral "Generation and biological evaluation of the products formed from the exposure of Phenothiazine to a 266nm laser beam", Proc. SPIE 8882, ROMOPTO 2012: Tenth Conference on Optics: Micro- to Nanophotonics III, 88820T (10 June 2013); https://doi.org/10.1117/12.2032666

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