Point-of-care optical tool to detect early stage of hemorrhage and shock

Rajan S. Gurjar; Suzannah L. Riccardi; Blair D. Johnson; Christopher P. Johnson; Norman A. Paradis; Michael J. Joyner; David E. Wolf

doi:10.1117/12.2040267

28 February 2014 Point-of-care optical tool to detect early stage of hemorrhage and shock

Rajan S. Gurjar, Suzannah L. Riccardi, Blair D. Johnson, Christopher P. Johnson, Norman A. Paradis, Michael J. Joyner, David E. Wolf

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Proceedings Volume 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics; 89510K (2014) https://doi.org/10.1117/12.2040267
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

There is a critical unmet clinical need for a device that can monitor and predict the onset of shock: hemorrhagic shock or bleeding to death, septic shock or systemic infection, and cardiogenic shock or blood flow and tissue oxygenation impairment due to heart attack. Together these represent 141 M patients per year. We have developed a monitor for shock based on measuring blood flow in peripheral (skin) capillary beds using diffuse correlation spectroscopy, a form of dynamic light scattering, and have demonstrated proof-of-principle both in pigs and humans. Our results show that skin blood flow measurement, either alone or in conjunction with other hemodynamic properties such as heart rate variability, pulse pressure variability, and tissue oxygenation, can meet this unmet need in a small self-contained patch-like device in conjunction with a hand-held processing unit. In this paper we describe and discuss the experimental work and the multivariate statistical analysis performed to demonstrate proof-of-principle of the concept.

Citation Download Citation

Rajan S. Gurjar, Suzannah L. Riccardi, Blair D. Johnson, Christopher P. Johnson, Norman A. Paradis, Michael J. Joyner, and David E. Wolf "Point-of-care optical tool to detect early stage of hemorrhage and shock", Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 89510K (28 February 2014); https://doi.org/10.1117/12.2040267

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KEYWORDS

Blood

Heart

Ear

Blood pressure

Skin

Tissues

Hemodynamics

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