Multimodal assessment of spatial distribution of drug-tracer uptake by brain tissue after intra-arterial injections

Rajinder Singh-Moon; Durba Chaudhuri; Mei Wang; Robert Straubinger; Irving J. Bigio; Shailendra Joshi

doi:10.1117/12.2040634

28 February 2014 Multimodal assessment of spatial distribution of drug-tracer uptake by brain tissue after intra-arterial injections

Rajinder Singh-Moon, Durba Chaudhuri, Mei Wang, Robert Straubinger, Irving J. Bigio, Shailendra Joshi

Author Affiliations +

Proceedings Volume 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics; 895113 (2014) https://doi.org/10.1117/12.2040634
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

It is challenging to track the rapid changes in drug concentrations after intra-arterial (IA) administration to elucidate the pharmacokinetics of this method of drug delivery. Traditional pharmacokinetic parameters (such as protein binding) that are highly relevant to intravenous (IV) administration do not seem to apply to IA injections. Regional drug delivery is affected by the biomechanics of drug injection, resting blood flow, and local tissue extraction. In-vivo and ex-vivo, optical methods for spatial mapping of drug deposition can assist in visualizing drug distributions and aid in the screening of potential drugs and carrier candidates. We present a multimodal approach for the assessment of drug distribution in postmortem tissue specimens using diffuse reflectance spectroscopy, multispectral imaging, and confocal microscopy and demonstrate feasibility of distinguishing route of administration advantages of liposome-dye conjugate delivery. The results of this study suggest that insight on drug dynamics gained by this aggregated approach can be used to help screen and/or optimize potential drug candidates and drug delivery protocols.

Citation Download Citation

Rajinder Singh-Moon, Durba Chaudhuri, Mei Wang, Robert Straubinger, Irving J. Bigio, and Shailendra Joshi "Multimodal assessment of spatial distribution of drug-tracer uptake by brain tissue after intra-arterial injections", Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 895113 (28 February 2014); https://doi.org/10.1117/12.2040634

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Brain

Tissues

Multispectral imaging

Tissue optics

Curium

Diffuse reflectance spectroscopy

Tumors

Show All Keywords

Keywords/Phrases

Search In:

Publication Years