Photodynamic Therapy Alone Or In Conjunction With Near-Infrared Light-Induced Hyperthermia In Human Malignant Tumors. A Methodological Case Study

S Andersson-Engels; J Johansson; D Killander; E Kjellen; M Oliva; L O Svaasand; K Svanberg; S Svanberg

doi:10.1117/12.945354

3 June 1988 Photodynamic Therapy Alone Or In Conjunction With Near-Infrared Light-Induced Hyperthermia In Human Malignant Tumors. A Methodological Case Study

S Andersson-Engels, J Johansson, D Killander, E Kjellen, M Oliva, L O Svaasand, K Svanberg, S Svanberg

Author Affiliations +

Proceedings Volume 0908, Laser Interaction with Tissue; (1988) https://doi.org/10.1117/12.945354
Event: 1988 Los Angeles Symposium: O-E/LASE '88, 1988, Los Angeles, CA, United States

Abstract

Several relevant physical parameters, such as superficial blood perfusion, temperature rise and tumor fluorescence characteristics, were monitored in an attempt to perform well-controlled photodynamic thera-py (PDT) on several human malignant tumors. DHE (Photofrin TT) was used as a photosensitizer at a concentration of 2 mg/kg b.w. administered i.v. 48-120 hours before treatment. 630 nm radiation from a CW dye laser, normally at an energy dose of 60 J/c10, at a dose rate well below the hyper-thermal region was delivered to seven 1-4 mm thick basal cell carcinoma lesions. PDT and near-infrared light-induced hyperthermia were performed simultaneously on six 5- 10 mm thick lesions of recurrent breast cancer in another patient. A filtered slide projector running at a power of about 200 mW/c1.0 with radiation above 665 nm was used for the light-induced hyperthermia. All the tumors were eradicated. PDT parameters and tissue temperature recordings were used as input data for an analytical PDT/hyperthermia model. The measured parameters have to be supplemented with assumed values for several other parameters. Although highly qualitative the model provides some interesting insight into the relative importance of PDT and hyperthermia.

Citation Download Citation

S Andersson-Engels, J Johansson, D Killander, E Kjellen, M Oliva, L O Svaasand, K Svanberg, and S Svanberg "Photodynamic Therapy Alone Or In Conjunction With Near-Infrared Light-Induced Hyperthermia In Human Malignant Tumors. A Methodological Case Study", Proc. SPIE 0908, Laser Interaction with Tissue, (3 June 1988); https://doi.org/10.1117/12.945354

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available