The papers included in this volume were part of the technical conference cited on the cover and title page. Papers were selected and subject to review by the editors and conference program committee. Some conference presentations may not be available for publication. The papers published in these proceedings reflect the work and thoughts of the authors and are published herein as submitted. The publisher is not responsible for the validity of the information or for any outcomes resulting from reliance thereon. Please use the following format to cite material from this book: Author(s), “Title of Paper,” in Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV, edited by šárka O. Southern, Mark A. Mentzer, Isaac Rodriguez-Chavez, Virginia E. Wotring, Proceedings of SPIE Vol. 9112 (SPIE, Bellingham, WA, 2014) Article CID Number. ISSN: 0277-786X ISBN: 9781628410495 Published by SPIE P.O. Box 10, Bellingham, Washington 98227-0010 USA Telephone +1 360 676 3290 (Pacific Time) · Fax +1 360 647 1445 SPIE.org Copyright © 2014, Society of Photo-Optical Instrumentation Engineers. Copying of material in this book for internal or personal use, or for the internal or personal use of specific clients, beyond the fair use provisions granted by the U.S. Copyright Law is authorized by SPIE subject to payment of copying fees. The Transactional Reporting Service base fee for this volume is $18.00 per article (or portion thereof), which should be paid directly to the Copyright Clearance Center (CCC), 222 Rosewood Drive, Danvers, MA 01923. Payment may also be made electronically through CCC Online at copyright.com. Other copying for republication, resale, advertising or promotion, or any form of systematic or multiple reproduction of any material in this book is prohibited except with permission in writing from the publisher. The CCC fee code is 0277-786X/14/$18.00. Printed in the United States of America. Publication of record for individual papers is online in the SPIE Digital Library. Paper Numbering: Proceedings of SPIE follow an e-First publication model, with papers published first online and then in print and on CD-ROM. Papers are published as they are submitted and meet publication criteria. A unique, consistent, permanent citation identifier (CID) number is assigned to each article at the time of the first publication. Utilization of CIDs allows articles to be fully citable as soon as they are published online, and connects the same identifier to all online, print, and electronic versions of the publication. SPIE uses a six-digit CID article numbering system in which: ■ The first four digits correspond to the SPIE volume number. ■ The last two digits indicate publication order within the volume using a Base 36 numbering system employing both numerals and letters. These two-number sets start with 00, 01, 02, 03, 04, 05, 06, 07, 08, 09, 0A, 0B … 0Z, followed by 10-1Z, 20-2Z, etc.
The CID Number appears on each page of the manuscript. The complete citation is used on the first page, and an abbreviated version on subsequent pages. Numbers in the index correspond to the last two digits of the six-digit CID Number. Conference CommitteeSymposium Chair Symposium Co-chair Conference Chair Conference Co-chairs Mark A. Mentzer, Neuroscience Applications Group, LLC (United States) Isaac Rodriguez-Chavez, National Institute of Dental and Craniofacial Research (United States) Virginia E. Wotring, Universities Space Research Association/NASA JSC (United States)
Conference Program Committee James Delehanty, U.S. Naval Research Laboratory (United States) Theresa G. Evans-Nguyen, Draper Laboratory (United States) Peter Kiesel, Palo Alto Research Center, Inc. (United States) Baochuan Lin, U.S. Naval Research Laboratory (United States) Daniel Malamud, New York University (United States) Igor Medintz, U.S. Naval Research Laboratory (United States) Richard M. Ozanich, Pacific Northwest National Laboratory (United States) Ava M. Puccio, University of Pittsburgh Medical Center (United States) Steven A. Ripp, The University of Tennessee (United States) Albert Skip Rizzo III, The University of Southern California (United States) Kim E. Sapsford, U.S. Food and Drug Administration (United States) Shadrian B. Strong, Johns Hopkins University Applied Physics Laboratory (United States) David E. Wolf, Radiation Monitoring Devices, Inc. (United States) Aurel Ymeti, Ostendum R&D BV (Netherlands)
Session Chairs 1 Non-invasive Disease Diagnostics for Global Health I Šárka O. Southern, Gaia Medical Institute (United States) Isaac R. Rodriguez-Chavez, National Institute of Dental and Craniofacial Research (United States) Daniel Malamud, New York University (United States) 2 Non-invasive Disease Diagnostics for Global Health II Timothy J. Griffin, University of Minnesota (United States) Charles F. Streckfus, The University of Texas at Houston (United States) Šárka O. Southern, Gaia Medical Institute (United States) 3 Military Medicine I: Traumatic Brain Injury and PTSD Mary E. Michel, National Institutes of Health (United States) Geoffrey Ling, Uniformed Services University of the Health Sciences (United States) Barry D. Jordan, Sports Concussion Institute (United States) 4 Military Medicine II: Physiology and Medicine of Extreme Environments and Spaceflight Virginia E. Wotring, Universities Space Research Association/NASA JSC (United States) Jonathan D. Stallings, U.S. Army Center for Environmental Health Research (United States) 5 Sensing Technologies for Disease Diagnostics and Environmental Monitoring I Stephen M. Hewitt, National Cancer Institute (United States) Richard Conroy, National Institutes of Health (United States) Šárka O. Southern, Gaia Medical Institute (United States) 6 Sensing Technologies for Disease Diagnostics and Environmental Monitoring II Stephen M. Hewitt, National Cancer Institute (United States) Claudia Gärtner, microfluidic ChipShop GmbH (Germany)
IntroductionThe 2014 SPIE Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring conference embraced a wealth of state-of-the-art information in basic and applied science. This event covered the latest developments in the following areas: • Non-invasive Disease Diagnostics for Global Health— This opening series of two consecutive sessions focused on oral biospecimen based rapid assays and point-of-care devices for the detection of pathogens causing infectious diseases, biomarkers for cancer, and analytes for non-communicable diseases such as diabetes. They also covered presentations on the human proteasome and microbiome with linkage to human diseases and diagnostic approaches. The sessions were built on the past experience and expertise of the National Institutes of Health, National Institutes of Dental and Craniofacial Research. • Military Medicine I: Traumatic Brain Injury and PTSD—This assembly covered oral-biomarker based diagnostics for brain damage and TBI as well as prevention and rehabilitation technologies. Neurorehabilitation and noninvasive neuromodulation were also discussed as critical approaches for effective functioning. • Military Medicine II: Physiology and Medicine of Extreme Environments and Spaceflight—This scientific segment showcased physiological, pharmacological and diagnostic sensing methodologies during spaceflight per the National Aeronautics and Space Administration as well as military-relevant toxicans and future sensing trends per the Department of Defense. It also included latest technologies to determine hydration status in warfighters, eye surgery using the latest laser technologies, and sensing tools for blood analysis. • Sensing Technologies for Disease Diagnostics and Environmental Monitoring—This closing series of two consecutive sessions provided the venues to learn and discuss more results on the next generation of diagnostic tools and field technologies for diseases, including biomarker detection by digital imaging, multiplex technologies, capillary electrophoresis and molecular platforms serving as labs-on-chips.
This conference allowed cross-fertilization of ideas, projects and collaborative work by a multidisciplinary audience of national and international colleagues from the academia, industry and federal government: The National Institutes of Health, National Aeronautics and Space Administration, and the Department of Defense. In 2015, this conference will enhance its focus on Global Health as an encompassing umbrella to include sensing technologies at early, medium and advanced level of development and implementation for communicable and non-communicable diseases impacting public and military health. The success of this conference lied in the compelling talks presented by distinguished speakers and the active and perceptive audience of colleagues who actively participated. The knowledge shared in this conference seeded projects that will translate into tangible and novel sensing tools to improve human health and quality of life. We look forward to enhancing the productivity and the success of this conference in 2015. Šárka O. Southern Isaac Rodriguez-Chavez
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