Optical tweezers for free-solution label-free single bio-molecule studies

Abhay Kotnala; Ahmed A. Al-Balushi; Reuven Gordon

doi:10.1117/12.2062051

16 September 2014 Optical tweezers for free-solution label-free single bio-molecule studies

Abhay Kotnala, Ahmed A. Al-Balushi, Reuven Gordon

Proceedings Volume 9164, Optical Trapping and Optical Micromanipulation XI; 916418 (2014) https://doi.org/10.1117/12.2062051
Event: SPIE NanoScience + Engineering, 2014, San Diego, California, United States

Abstract

Nanoaperture based trapping has developed as a significant tool among the various optical tweezer systems for trapping of very small particles down to the single nanometer range. The double nanohole aperture based trap provides a method for efficient, highly-sensitive, label-free, low-cost, free-solution single molecule trapping and detection. We use the double nanohole tweezer to understand biomolecular phenomena like protein unfolding, binding, structural conformation of DNA, protein-DNA interactions, and protein small molecule interactions.

Citation Download Citation

Abhay Kotnala, Ahmed A. Al-Balushi, and Reuven Gordon "Optical tweezers for free-solution label-free single bio-molecule studies", Proc. SPIE 9164, Optical Trapping and Optical Micromanipulation XI, 916418 (16 September 2014); https://doi.org/10.1117/12.2062051

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