In vitro determination of glucose concentration based on photoacoustic spectroscopy and chemometrics

Zhong Ren; Guodong Liu; Zhen Huang

doi:10.1117/12.2066975

17 September 2014 In vitro determination of glucose concentration based on photoacoustic spectroscopy and chemometrics

Zhong Ren, Guodong Liu, Zhen Huang

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 923004 (2014) https://doi.org/10.1117/12.2066975
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Noninvasive blood glucose level (BGL) monitoring has recently become a research hotspot in the world. Photoacoustic spectroscopy is a well-established, hybrid and promising noninvasive technique, which has already drawn many researchers’ attentions in recent years due to the advantage of overcoming the scattering light interference. As the preliminary exploration of photoacoustic BGL monitoring, a photoacoustic BGL monitoring set-up based on nanosecond pulsed laser with repetition rate of 20Hz and ultrasound transducer with central frequency of 9.55MHz was established in this paper. To explore the mechanism of the time resolved BGL photoacoustic signal, a series of in vitro experiments of glucose aqueous solutions were tested, the time resolved photoacoustic signals for different concentrations of glucose solutions under different output wavelengths were captured with the data average of 512 times. The peak-to-peak values of each solution were gotten at the wavelength interval of 10nm. Difference with the peak-to-peak value of pure water via subtractive spectroscopy, the characteristic wavelengths of glucose were gotten, and the optimum characteristic wavelengths were determined via data pre-processing and principle component analysis(PCA) algorithm, the calibration equation between concentration and the peak-to-peak value was gotten via multiple linear regression(MLR), and the calibration root mean square error(CRMSE) and the prediction root mean square error(PRMSE) of glucose level is all less than 10mg/dl under the correction equation.

Citation Download Citation

Zhong Ren, Guodong Liu, and Zhen Huang "In vitro determination of glucose concentration based on photoacoustic spectroscopy and chemometrics", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923004 (17 September 2014); https://doi.org/10.1117/12.2066975

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Photoacoustic spectroscopy

Glucose

Signal detection

Pulsed laser operation

Acoustics

Light scattering

Transducers

Show All Keywords

Keywords/Phrases

Search In:

Publication Years