Intravascular photoacoustic tomography for characterization of atherosclerotic lipid and inflammation

Jian Zhang; Huan Qin; Yujiao Shi; Sihua Yang; Da Xing

doi:10.1117/12.2069044

17 September 2014 Intravascular photoacoustic tomography for characterization of atherosclerotic lipid and inflammation

Jian Zhang, Huan Qin, Yujiao Shi, Sihua Yang, Da Xing

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 923027 (2014) https://doi.org/10.1117/12.2069044
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Photoacoustic imaging is a fast growing imaging technology depending on its high optical resolution of optics while taking the advantage of the high penetration depth of ultrasound. In this paper, we demonstrate the new progress in the photoacoustic imaging. Atherosclerosis is characterized by a progressive build-up of lipid in the arterial wall, which is known as plaque. Histological studies demonstrate that the primary cause of acute cardiovascular events is the rupture of atherosclerotic plaques. Lipid and inflammation within the plaque are related to influence the propensity of plaques to disrupt. Photoacoustic intravascular tomography (IVPAT) holds a great advantage in providing comprehensive morphological and functional information of plaques. Lipid relative concentration maps of atherosclerotic aorta were obtained and compared with histology. Furthermore, by selectively targeting the intravascular inflammatory cytokines, IVPAT is also capable of mapping the inflamed area and determining the degree of inflammation.

Citation Download Citation

Jian Zhang, Huan Qin, Yujiao Shi, Sihua Yang, and Da Xing "Intravascular photoacoustic tomography for characterization of atherosclerotic lipid and inflammation", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923027 (17 September 2014); https://doi.org/10.1117/12.2069044

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