Ultrasensitive quantification of cerebral capillary flow networks and dynamics

Jiang You; Ki Park; Congwu Du; Yingtian Pan

doi:10.1117/12.2082428

2 March 2015 Ultrasensitive quantification of cerebral capillary flow networks and dynamics

Jiang You, Ki Park, Congwu Du, Yingtian Pan

Proceedings Volume 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX; 931218 (2015) https://doi.org/10.1117/12.2082428
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Ultra-high resolution optical Doppler coherence tomography (μODT) is a promising tool for brain functional imaging. However, its sensitivity for detecting slow flows in capillary beds may limit its utility in visualizing and quantifying subtle changes in brain microcirculation. To address this limitation, we developed a novel method called contrast-enhanced μODT (c-μODT) in which intralipid is injected into mouse tail vein to enhance μODT detection sensitivity. We demonstrate that after intralipid injection, the flow detection sensitivity of μODT is dramatically enhanced by 230% as quantified by the fill factor (FF) of microvasculature. More importantly, we show that c-μODT preserves the quantitative properties for flow imaging, i.e., showing a comparable change ratio of hypercapnia-induced flow increase in the capillary network before and after injecting intralipid.

Citation Download Citation

Jiang You, Ki Park, Congwu Du, and Yingtian Pan "Ultrasensitive quantification of cerebral capillary flow networks and dynamics", Proc. SPIE 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX, 931218 (2 March 2015); https://doi.org/10.1117/12.2082428

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
5 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Capillaries

Brain

Neuroimaging

Doppler tomography

Optical coherence tomography

Image sensors

Sensorimotor cortex

Show All Keywords

Keywords/Phrases

Search In:

Publication Years