Amplitude-modulated ultrasound radiation force combined with phase-sensitive optical coherence tomography for shear wave elastography

Thu-Mai Nguyen; Shaozhen Song; Bastien Arnal; Emily Y. Wong; Tueng T. Shen; Ruikang K. Wang; Matthew O'Donnell

doi:10.1117/12.2084609

6 March 2015 Amplitude-modulated ultrasound radiation force combined with phase-sensitive optical coherence tomography for shear wave elastography

Thu-Mai Nguyen, Shaozhen Song, Bastien Arnal, Emily Y. Wong, Tueng T. Shen, Ruikang K. Wang, Matthew O'Donnell

Author Affiliations +

Proceedings Volume 9327, Optical Elastography and Tissue Biomechanics II; 932705 (2015) https://doi.org/10.1117/12.2084609
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Tissue stiffness can be measured from the propagation speed of shear waves. Acoustic radiation force (ARF) can generate shear waves by focusing ultrasound in tissue for ~100 μs. Safety considerations and electronics abilities limit ultrasound pressures. We previously presented shear wave elastography combining ARF and phase-sensitive optical coherence tomography (PhS-OCT) [1]. Here, we use amplitude-modulated ARF to enhance shear wave signal-to-noise ratio (SNR) at low pressures. Experiments were performed on tissue-mimicking phantoms. ARF was applied using a single-element transducer, driven by a 7.5 MHz, 3-ms, sine wave modulated in amplitude by a linear-swept frequency (1 to 7 kHz). Pressures between 1 to 3 MPa were tested. Displacements were tracked using PhS-OCT and numerically compressed using pulse compression methods detailed in previous work [2]. SNR was compared to that of 200-μs bursts. Stiffness maps were reconstructed using time-of-flight computations. 200-μs bursts give barely detectable displacements at 1 MPa (3.7 dB SNR). Pulse compression gives 36.2 dB at 1.5 MPa. In all cases with detectable displacements, shear wave speeds were determined in 5%-gelatin and 10%-gelatin phantoms and compared to literature values. Applicability to ocular tissues (cornea, intraocular lens) is under investigation.

Citation Download Citation

Thu-Mai Nguyen, Shaozhen Song, Bastien Arnal, Emily Y. Wong, Tueng T. Shen, Ruikang K. Wang, and Matthew O'Donnell "Amplitude-modulated ultrasound radiation force combined with phase-sensitive optical coherence tomography for shear wave elastography", Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 932705 (6 March 2015); https://doi.org/10.1117/12.2084609

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