Multifunctional metal rattle-type nanocarriers for MRI-guided photothermal cancer therapy

Yuran Huang; Tuo Wei; Jing Yu; Yanglong Hou; Kaiyong Cai; Xing-jie Liang

doi:10.1117/12.2073332

12 March 2015 Multifunctional metal rattle-type nanocarriers for MRI-guided photothermal cancer therapy

Yuran Huang, Tuo Wei, Jing Yu, Yanglong Hou, Kaiyong Cai, Xing-jie Liang

Proceedings Volume 9338, Colloidal Nanoparticles for Biomedical Applications X; 933803 (2015) https://doi.org/10.1117/12.2073332
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Numerous nanomaterials have been developed for biomedical application, especially cancer therapy. Visualizing cancer therapy is highly promising now because of the potential ability to realize accurate, localized treatment. In this work, we firstly synthesized metal nanorattles (MNRs), which utilized porous gold shells capable of photothermal therapy to carry multiple superparmagnetic iron oxide nanoparticles (SPIONs) as MR imaging contrast agents inside. As shown in the infrared light, these metal rattle-typed nanostructures were able to convert to heat to kill cells, and inhibit tumor growth. As a carrier for multiple SPIONs, it also performed a good behavior for T2-weighted MR imaging in tumor site. Moreover, the rest of the inner space of the gold shell also introduced potential ability as nanocarriers for other cargos such as chemotherapeutic drugs, which is still under investigation. This metal-rattle-type nanocarriers is highly potential as a novel platforms for cancer therapy in the future.

Citation Download Citation

Yuran Huang, Tuo Wei, Jing Yu, Yanglong Hou, Kaiyong Cai, and Xing-jie Liang "Multifunctional metal rattle-type nanocarriers for MRI-guided photothermal cancer therapy", Proc. SPIE 9338, Colloidal Nanoparticles for Biomedical Applications X, 933803 (12 March 2015); https://doi.org/10.1117/12.2073332

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