Atomistic modeling of the structural components of the blood-brain barrier

O. E. Glukhova; O. A. Grishina; M. M. Slepchenkov

doi:10.1117/12.2180071

19 March 2015 Atomistic modeling of the structural components of the blood-brain barrier

O. E. Glukhova, O. A. Grishina, M. M. Slepchenkov

Proceedings Volume 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics; 94481G (2015) https://doi.org/10.1117/12.2180071
Event: Saratov Fall Meeting 2014, 2014, Saratov, Russian Federation

Abstract

Blood-brain barrier, which is a barrage system between the brain and blood vessels, plays a key role in the "isolation" of the brain of unnecessary information, and reduce the "noise" in the interneuron communication. It is known that the barrier function of the BBB strictly depends on the initial state of the organism and changes significantly with age and, especially in developing the "vascular accidents". Disclosure mechanisms of regulation of the barrier function will develop new ways to deliver neurotrophic drugs to the brain in the newborn. The aim of this work is the construction of atomistic models of structural components of the blood-brain barrier to reveal the mechanisms of regulation of the barrier function.

Citation Download Citation

O. E. Glukhova, O. A. Grishina, and M. M. Slepchenkov "Atomistic modeling of the structural components of the blood-brain barrier", Proc. SPIE 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics, 94481G (19 March 2015); https://doi.org/10.1117/12.2180071

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