Tissue perfusability assessment from capillary velocimetry data via the multicompartment Windkessel model

Elena S. Stiukhina; Maxim A. Kurochkin; Victor A. Klochkov; Ivan V. Fedosov; Dmitry E. Postnov

doi:10.1117/12.2179870

19 March 2015 Tissue perfusability assessment from capillary velocimetry data via the multicompartment Windkessel model

Elena S. Stiukhina, Maxim A. Kurochkin, Victor A. Klochkov, Ivan V. Fedosov, Dmitry E. Postnov

Proceedings Volume 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics; 94481K (2015) https://doi.org/10.1117/12.2179870
Event: Saratov Fall Meeting 2014, 2014, Saratov, Russian Federation

Abstract

A method is presented to obtain information on tissue perfusability from capillary velocimetry experiments coupled with venous occlusion probe. The method based on data fitting to developed mathematical model describing the blood flow redistribution caused by the introduced occlusion. Using mathematical modeling, we identify the segment of velocity time courses that corresponds to tissue swelling process and thus allows ones quantify it. We also compared the results of direct measurement of red blood cells (RBCs) velocity with time courses obtained from finger-placed sensors of two types: (i) photoplethysmographic sensor used in pulsometry and (ii) piezoelectric sensor for sphygmography. The obtained results suggest the measurable contribution of RBCs aggregation process in optical pulse signal formation.

Citation Download Citation

Elena S. Stiukhina, Maxim A. Kurochkin, Victor A. Klochkov, Ivan V. Fedosov, and Dmitry E. Postnov "Tissue perfusability assessment from capillary velocimetry data via the multicompartment Windkessel model", Proc. SPIE 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics, 94481K (19 March 2015); https://doi.org/10.1117/12.2179870

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