Aortic atherosclerotic plaque detection using a multiwavelength handheld photoacoustic imaging system

Susumu Hirano; Takeshi Namita; Kengo Kondo; Makoto Yamakawa; Tsuyoshi Shiina

doi:10.1117/12.2212256

15 March 2016 Aortic atherosclerotic plaque detection using a multiwavelength handheld photoacoustic imaging system

Susumu Hirano, Takeshi Namita, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

Proceedings Volume 9708, Photons Plus Ultrasound: Imaging and Sensing 2016; 97084Y (2016) https://doi.org/10.1117/12.2212256
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Patients affected by diseases caused by arteriosclerosis are increasing. Atherosclerosis, which is becoming an especially difficult health problem, forms plaques from lipids such as cholesterol located in walls of the aorta, cerebral artery, and coronary artery. Because lipid-rich plaques are vulnerable and because arterial rupture causes acute vascular occlusion, early detection is crucially important to prevent plaque growth and rupture. Ultrasound systems can detect plaques but cannot discriminate between vulnerable and equable plaques. To evaluate plaques non-invasively and easily, we developed a handheld photoacoustic imaging device. Its usefulness was verified in phantom experiments with a bovine aorta in which mimic plaque had been embedded. Photoacoustic images taken at wavelengths that produce high light absorbance by lipids show strong photoacoustic signals from the boundary of the mimic plaque. Results confirmed that our system can evaluate plaque properties by analysis with the photoacoustic spectrum. The effects of surrounding tissues and tissue components on plaque evaluation were investigated using a layered phantom. The mimic plaque located under a 6 mm blood layer was also evaluated. Results of these analyses demonstrate the system’s usefulness.

Citation Download Citation

Susumu Hirano, Takeshi Namita, Kengo Kondo, Makoto Yamakawa, and Tsuyoshi Shiina "Aortic atherosclerotic plaque detection using a multiwavelength handheld photoacoustic imaging system", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97084Y (15 March 2016); https://doi.org/10.1117/12.2212256

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available