Advanced laser system for 3D optoacoustic tomography of the breast

Marc Klosner; Gary Chan; Chunbai Wu; Donald F. Heller; Richard Su; Sergey Ermilov; Hans Peter Brecht; Vassili Ivanov; Pratik Talole; Yang Lou; Mark Anastasio; Alexander Oraevsky

doi:10.1117/12.2209398

29 March 2016 Advanced laser system for 3D optoacoustic tomography of the breast

Marc Klosner, Gary Chan, Chunbai Wu, Donald F. Heller, Richard Su, Sergey Ermilov, Hans Peter Brecht, Vassili Ivanov, Pratik Talole, Yang Lou, Mark Anastasio, Alexander Oraevsky

Author Affiliations +

Proceedings Volume 9708, Photons Plus Ultrasound: Imaging and Sensing 2016; 97085B (2016) https://doi.org/10.1117/12.2209398
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We describe the ongoing development and performance of a high-pulse-energy wavelength-cycling laser system for three-dimensional optoacoustic tomography of the breast. Joule-level energies are desired for achieving the required penetration depths while maintaining safe fluence levels. Wavelength cycling provides a pulse sequence which repeatedly alternates between two wavelengths (approximately 756 and 797 nm) that provide differential imaging. This improves co-registration of captured differential images and quantification of blood oxygen saturation. New design features have been developed for and incorporated into a clinical prototype laser system, to improve efficacy and ease of use in the clinic. We describe the benefits of these features for operation with a clinical pilot optoacoustic / ultrasound dual-modality three-dimensional imaging system.

Citation Download Citation

Marc Klosner, Gary Chan, Chunbai Wu, Donald F. Heller, Richard Su, Sergey Ermilov, Hans Peter Brecht, Vassili Ivanov, Pratik Talole, Yang Lou, Mark Anastasio, and Alexander Oraevsky "Advanced laser system for 3D optoacoustic tomography of the breast", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97085B (29 March 2016); https://doi.org/10.1117/12.2209398

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