Thalamus parcellation using multi-modal feature classification and thalamic nuclei priors

Jeffrey Glaister; Aaron Carass; Joshua V. Stough; Peter A. Calabresi; Jerry L. Prince

doi:10.1117/12.2216987

21 March 2016 Thalamus parcellation using multi-modal feature classification and thalamic nuclei priors

Jeffrey Glaister, Aaron Carass, Joshua V. Stough, Peter A. Calabresi, Jerry L. Prince

Proceedings Volume 9784, Medical Imaging 2016: Image Processing; 97843J (2016) https://doi.org/10.1117/12.2216987
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

Segmentation of the thalamus and thalamic nuclei is useful to quantify volumetric changes from neurodegenerative diseases. Most thalamus segmentation algorithms only use T1-weighted magnetic resonance images and current thalamic parcellation methods require manual interaction. Smaller nuclei, such as the lateral and medial geniculates, are challenging to locate due to their small size. We propose an automated segmentation algorithm using a set of features derived from diffusion tensor image (DTI) and thalamic nuclei location priors. After extracting features, a hierarchical random forest classifier is trained to locate the thalamus. A second random forest classifies thalamus voxels as belonging to one of six thalamic nuclei classes. The proposed algorithm was tested using a leave-one-out cross validation scheme and compared with state-of-the-art algorithms. The proposed algorithm has a higher Dice score compared to other methods for the whole thalamus and several nuclei.

Citation Download Citation

Jeffrey Glaister, Aaron Carass, Joshua V. Stough, Peter A. Calabresi, and Jerry L. Prince "Thalamus parcellation using multi-modal feature classification and thalamic nuclei priors", Proc. SPIE 9784, Medical Imaging 2016: Image Processing, 97843J (21 March 2016); https://doi.org/10.1117/12.2216987

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