Cellular And Preclinical Examination Of Photodynamic Therapy

Charles J. Gomer; Angela Ferrario; Natalie Rucker; Sam Wong; Elisa Morinelli; Grace Liu; Bernard C. Szirth

doi:10.1117/12.960178

17 March 1989 Cellular And Preclinical Examination Of Photodynamic Therapy

Charles J. Gomer, Angela Ferrario, Natalie Rucker, Sam Wong, Elisa Morinelli, Grace Liu, Bernard C. Szirth

Proceedings Volume 0997, Advances in Photochemotherapy; (1989) https://doi.org/10.1117/12.960178
Event: O-E/Fiber LASE '88, 1988, Boston, MA, United States

Abstract

In-vitro studies have been performed to compare the mode of action of porphyrin induced photodynamic therapy and hyperthermia. Parent and temperature resistant clones of Chinese hamster and mouse fibrosarcoma cells were treated with either PDT or hyperthermia. Quantitative survival curves obtained from these experiments indicate that temperature resistant cells are not cross resistant to PDT even though both treatments induce the synthesis of stress proteins. In-vivo studies were performed to evaluate the photosensitizing efficiency to mono-l-aspartyl chlorin e 6 (NPe6). Tumor response and normal skin response were determined using a murine tumor system. The studies indicate that NPe6 is an extremely effective tumor photosensitizer with rapid in-vivo clearance properties which may eliminate the side effects of prolonged and systemic skin photosensitivity.

Citation Download Citation

Charles J. Gomer, Angela Ferrario, Natalie Rucker, Sam Wong, Elisa Morinelli, Grace Liu, and Bernard C. Szirth "Cellular And Preclinical Examination Of Photodynamic Therapy", Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); https://doi.org/10.1117/12.960178

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