Tissue and cellular imaging enabled by a fiber laser with optimized balanced detector

Maximilian Brinkmann; Maryam Rezaei; Felix Neumann; Ramon Droop; Christoph Engwer; Niklas Lüpken; Sven Dobner; Tim Hellwig

doi:10.1117/12.3001402

13 March 2024 Tissue and cellular imaging enabled by a fiber laser with optimized balanced detector

Maximilian Brinkmann, Maryam Rezaei, Felix Neumann, Ramon Droop, Christoph Engwer, Niklas Lüpken, Sven Dobner, Tim Hellwig

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Proceedings Volume PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry; PC128390O (2024) https://doi.org/10.1117/12.3001402
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Hyperspectral Stimulated Raman Imaging (SRS) has shown great promise as a label-free chemical imaging technique in biomedical and medical research. We present recent developments in SRS integrating a compact and portable all-fiber laser with balanced detection into an imaging system, aiming to enhance ease-of-use, specificity, and reliability in acquiring high-speed, multicolor chemical images. The system's adaptability is highlighted by integrating the entire microscopy system into a clinical cart, ensuring clinical compatibility as well as its seamless integration with a Nikon Eclipse Ti widefield microscope, providing a compact and robust extension for varied imaging setups. The system incorporates a balanced detector to enable shot-noise-limited measurements, accommodating over 100mW of Stokes power on the detector.

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Citation Download Citation

Maximilian Brinkmann, Maryam Rezaei, Felix Neumann, Ramon Droop, Christoph Engwer, Niklas Lüpken, Sven Dobner, and Tim Hellwig "Tissue and cellular imaging enabled by a fiber laser with optimized balanced detector", Proc. SPIE PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry, PC128390O (13 March 2024); https://doi.org/10.1117/12.3001402

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KEYWORDS

Fiber lasers

Tissues

Imaging technologies

Biomedical optics

Medical research

Microscopy

Raman spectroscopy

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