Photoacoustic fiberscope for cerebral oxygenation imaging of freely-moving mouse

Xiaoxuan Zhong; Yizhi Liang; Long Jin

doi:10.1117/12.3004125

13 March 2024 Photoacoustic fiberscope for cerebral oxygenation imaging of freely-moving mouse

Xiaoxuan Zhong, Yizhi Liang, Long Jin

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128420B (2024) https://doi.org/10.1117/12.3004125
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We report a head-mounted photoacoustic fiberscope for cerebral imaging in a freely behaving mouse. The 4.5-gram imaging probe has a 9-µm lateral resolution and 0.2-Hz frame rate over a 1.2-mm wide area. The probe can continuously monitor cerebral oxygenation and hemodynamic responses at single-vessel resolution, showing significantly different cerebrovascular responses to external stimuli under anesthesia and in the freely moving state. When mice subjected to high-concentration CO₂ respiration, enhanced oxygenation to compensate for hypercapnia can be visualized in freely moving state. Comparative studies exhibit significantly weakened compensation capabilities in obese mice. This new imaging modality shows promise in neuroscience studies.

Conference Presentation

Citation Download Citation

Xiaoxuan Zhong, Yizhi Liang, and Long Jin "Photoacoustic fiberscope for cerebral oxygenation imaging of freely-moving mouse", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128420B (13 March 2024); https://doi.org/10.1117/12.3004125

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