The presentation will overview our on-going activities on the development of novel artificial materials (metamaterials), which are expected to improve current state-of-the-art label-free optical biosensing. The focus will be given to topologically dark metamaterials, which can provide the phenomenon of darkness (TD). Such a phenomenon consists in exactly zero light reflection/transmission from a dedicated optical system, which is topologically protected by spectral properties of optical constants of materials and the positioning of the zero reflection/transmission surface, and survives any structural imperfections. One of interesting effects, accompanying TD, consists in the generation of extreme singularities of phase of light reflected from a sensor transducer. When used as a sensing parameter to control biomolecular interactions, phase singularities can provide a breakthrough in sensitivity, which promises a major upgrade in the label-free detection .
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