Non-thermal protein structural change by THz pulsed light irradiation

Kyosuke Makino; Kazuhiko Misawa; Terumasa Ito; Hironori Ito

doi:10.1117/12.3007091

12 March 2024 Non-thermal protein structural change by THz pulsed light irradiation

Kyosuke Makino, Kazuhiko Misawa, Terumasa Ito, Hironori Ito

Proceedings Volume PC12885, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XVII; PC128850S (2024) https://doi.org/10.1117/12.3007091
Event: SPIE OPTO, 2024, San Francisco, California, United States

Abstract

Terahertz (THz) light that resonates with the vibrational frequency of hydrated water molecules, can alter functional expression of proteins. Previous studies have shown that high-intensity THz light promotes actin fiber formation, but such mechanism is not comprehensively investigated. Here, we aim to clarify this mechanism by irradiating actin solution with THz pulsed light of lower average power and higher electric field intensity to suppress thermal effects. We compare the degree of fiber formation with and without irradiation. The result shows the contribution of electric field intensity in the accelerated actin fiber formation and clarifies the existence of non-thermal effects.

Conference Presentation

Citation Download Citation

Kyosuke Makino, Kazuhiko Misawa, Terumasa Ito, and Hironori Ito "Non-thermal protein structural change by THz pulsed light irradiation", Proc. SPIE PC12885, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XVII, PC128850S (12 March 2024); https://doi.org/10.1117/12.3007091

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